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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PAPPA2
All Species:
4.55
Human Site:
S445
Identified Species:
12.5
UniProt:
Q9BXP8
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BXP8
NP_064714.2
1791
198539
S445
F
Q
H
S
S
Q
H
S
S
G
E
E
E
A
T
Chimpanzee
Pan troglodytes
XP_514020
1791
198653
S445
F
Q
H
S
S
Q
H
S
S
G
E
E
E
A
T
Rhesus Macaque
Macaca mulatta
XP_001095160
1573
175281
M305
T
Q
K
C
K
V
L
M
L
G
G
S
A
L
N
Dog
Lupus familis
XP_537179
1778
195855
P436
L
Q
H
S
P
Q
H
P
T
G
V
G
E
L
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4K8
1624
181300
N356
V
V
R
Y
R
V
V
N
I
Y
D
D
H
H
E
Rat
Rattus norvegicus
XP_001073420
1788
198541
P445
L
Q
H
S
P
Q
H
P
S
G
V
D
E
L
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_426627
1551
171156
R283
Y
N
R
H
W
P
L
R
G
A
K
V
V
R
Y
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_695417
1759
195473
H441
L
L
K
S
H
Q
P
H
S
E
R
Q
S
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_795597
1601
177169
P333
I
S
D
I
Q
R
H
P
S
Y
P
H
V
T
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
39.7
81.7
N.A.
43.6
79.4
N.A.
N.A.
57.9
N.A.
48
N.A.
N.A.
N.A.
N.A.
33.6
Protein Similarity:
100
99.7
56.3
89
N.A.
60
87.2
N.A.
N.A.
68.2
N.A.
63.8
N.A.
N.A.
N.A.
N.A.
49
P-Site Identity:
100
100
13.3
46.6
N.A.
0
60
N.A.
N.A.
0
N.A.
20
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
13.3
60
N.A.
20
66.6
N.A.
N.A.
13.3
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
12
0
0
12
23
12
% A
% Cys:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
12
0
0
0
0
0
0
0
12
23
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
12
23
23
45
0
12
% E
% Phe:
23
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
12
56
12
12
0
0
0
% G
% His:
0
0
45
12
12
0
56
12
0
0
0
12
12
12
0
% H
% Ile:
12
0
0
12
0
0
0
0
12
0
0
0
0
0
0
% I
% Lys:
0
0
23
0
12
0
0
0
0
0
12
0
0
0
0
% K
% Leu:
34
12
0
0
0
0
23
0
12
0
0
0
0
34
12
% L
% Met:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% M
% Asn:
0
12
0
0
0
0
0
12
0
0
0
0
0
0
12
% N
% Pro:
0
0
0
0
23
12
12
34
0
0
12
0
0
12
0
% P
% Gln:
0
56
0
0
12
56
0
0
0
0
0
12
0
0
0
% Q
% Arg:
0
0
23
0
12
12
0
12
0
0
12
0
0
12
0
% R
% Ser:
0
12
0
56
23
0
0
23
56
0
0
12
12
0
12
% S
% Thr:
12
0
0
0
0
0
0
0
12
0
0
0
0
12
34
% T
% Val:
12
12
0
0
0
23
12
0
0
0
23
12
23
0
0
% V
% Trp:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
12
0
0
12
0
0
0
0
0
23
0
0
0
0
12
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _